Multi-species Ontologies of the Craniofacial Musculoskeletal System

نویسندگان

  • José L. V. Mejino
  • James F. Brinkley
  • Timothy C. Cox
  • Landon Fridman Detwiler
چکیده

We created the Ontology of Craniofacial Development and Malformation (OCDM) [1] to provide a unifying framework for organizing and integrating craniofacial data ranging from genes to clinical phenotypes from multi-species. Within this framework we focused on spatio-structural representation of anatomical entities related to craniofacial development and malformation, such as craniosynostosis and midface hypoplasia. Animal models are used to support human studies and so we built multi-species ontologies that would allow for cross-species correlation of anatomical information. For this purpose we first developed and enhanced the craniofacial component of the human musculoskeletal system in the Foundational Model of Anatomy Ontology (FMA)[2], and then imported this component, which we call the Craniofacial Human Ontology (CHO), into the OCDM. The CHO was then used as a template to create the anatomy for the mouse, the Craniofacial Mouse Ontology (CMO) as well as for the zebrafish, the Craniofacial Zebrafish Ontology (CZO).

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عنوان ژورنال:
  • CEUR workshop proceedings

دوره 1747  شماره 

صفحات  -

تاریخ انتشار 2016